hrp0086p2-p266 | Diabetes P2 | ESPE2016

Gene-Environment (GxE) Interactions in Childhood Type 1 Diabetes (T1D): A Case-only Geographical Approach in the ISIS-Diab Cohort

Bougneres Pierre , Fur Sophie Le , Valtat Sophie , Lathrop Mark , Valleron Alain-Jacques , ISIS-Diab Network France

Background: T1D concordance in MZ twins being ~40%, non-heritable factors play a major causal role in this autoimmune disease. T1D has recently increased in young European children. Collecting prospective environmental data in a cohort of millions children-years starting soon after birth seems unpracticable. Retrospective caseĀ–control studies are an alternative, provided biased controls and recall bias can both be avoided.Objectives: To develop a &#...